HARDWARE

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

SENSORS

 

 

 

 

 

 

 

 

SOFTWARE

 

 

 

 

 

 

 

 

 

UTILITIES &

DIMENSIONS

 

 

 

11CO2 Trapping

 

 

 

Reactors

 

 

 

 

AgOTf column

 

 

Labelling reaction

 

 

Process Valves

 

 

HPLC Valves

 

 

 

HPLC pump

 

 

HPLC UV detector

 

 

Product reformulation

 

 

Automation

 

Other features

 

 

 

Radioactivity

 

Pressure

 

Flow

 

Temperature

 

 

Graphical interface

 

 

Synthesis recipes

 

 

HPLC control

 

 

 

Compressed Air

 

Inert Gas

 

Case

 

 

Dimensions

 

 

 

• Solid phase room temperature trapping of 11CO2 onto molecular sieve

• Rapid heating to 250°C (11CO2 releases at 180°C)

• Compressed air cooling

 

• Dual 1.1mL disposable tapered bottom glass reactors

• Rapid heating to 250°C and compressed air cooling

• Production of methyl-iodide in reactor 1 via the "wet chemistry" method

• Reactor 2 used for labelling reactions with syringe driven HPLC loop loading

 

• Built-in with rapid heating up to 250°C for online conversion of methyl-iodide into methyl-triflate

 

• Either by traditional reaction vial (Reactor 2) or

• Room temperature loop labelling*

 

• 9 Electric multi-position valves

• 13.6 bar (200psi), 1.32 mm orifice, 20uL internal volume

 

• Built-in automatic injector

• Manual injector (for precursor loading for loop labelling reactions with 2mL stainless steel loop

 

• Knauer 50 mL/min pump

• Optional quaternary L.P.G. & quad channel degasser

 

• Knauer detector with remote fibre optic flow cell

• Variable wavelength (190-750 nm)

 

• Disposable sterile kit with reverse phase S.P.E. cartridge reformulation

• Non-proprietary commercially available components

 

• Industrial PLC with Ethernet communications

 

• All compressed air used for reactor or column cooling is contained and can be exhausted outside of the hotcell to avoid hotcell contamination or pressurization

 

 

• 6-collimated linear CsI(TI) crystal PIN diode radioactivity detectors

 

• Pressure sensor for inert gas pressure monitoring

 

• Mass Flow Controller for precise inert gas metering

 

• 4 thermocouple sensors for reactor and column heaters

 

 

• Easy to use open platform operator interface, with sensor trends, historical data logging & analysis, synthesis reports, multi-level user access

 

• Easily generated using unique Click-&-Save graphical technology and stored as Excel® step lists

 

• HPLC pump flow, eluent composition and gradients controlled directly from C-11 Pro2's graphical interface (with optional LPG module)

 

 

• 6-8 bar (87-116 psi), 6 mm O.D. connection

 

• Helium, Nitrogen or Argon, 2-8 bar (29-116 psi)

 

• Compact 316 stainless steel

• Easy installation

 

• 510 mm x 415 mm x 340 mm (WxHxD)

C-11 PRO2 TECHNICAL SPECIFICATIONS

* Loop labelling method developed by A. Wilson et al. 2000

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