FlexLab
multi-step F-18 radiotracer production lab The FlexLab is the most versatile F-18 radiosynthesizer specifically suited to the research, development and fully automated production of multi-step radiotracers. The FlexLab allows the radiochemist to fully automate the radiosynthesis of multi-step compounds thereby improving synthesis yields, simplifying daily production and most importantly reducing the operators radiation exposure by completely eliminating the need of preform any manual processes.
For complex multi step F-18 radiotracer research & development, the FlexLab has been invaluable Dr. Uwe Ackermann
Chief Research Radiochemist Austin Hospital, Australia
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Open Up New Possibilities
The FlexLab is the only radiosynthesizer that is able to fully automate all the following synthesis steps:
Step 1:
18F Trapping onto QMA Step 2:
Reactor 1:
Primary Reaction Step 3:
SPE Purification of Primary Reaction Mixture Step 4:
HPLC Purification of Primary Reaction Mixture Step 5:
SPE Reformulation of Primary HPLC product
Step 6:
Reactor 2:
Secondary Reaction Step 7:
SPE Purification of Secondary Reaction Mixture Step 8:
HPLC Purification of Secondary Reaction Mixture Step 9:
SPE Reformulation of Secondary HPLC product Step 10:
Final Injectable Radiotracer
HPLC Without Limitations
The FlexLab's HPLC system has been designed to give radiochemist's all the tools they need to purify complex compounds multi-step compounds without any compromises.
FlexLab close-up
Dual HPLC Injectors
Allows two independent HPLC purifications in the one synthesis using independent HPLC loops & HPLC columns. Dual HPLC Column Selector
Automatically select between two different HPLC columns and also provide a column by-pass. Dual HPLC Product SPE Reformulation
Perform two independent S.P.E. purification of the collected HPLC product (one per HPLC system).
4 x HPLC Eluents
Automatic selection between the 4 eluents. Fibre Optic UV/VIS Detector
Variable wavelength with a remote fibre optic flow cell. Quaternary Low Pressure Gradient HPLC Pump
50mL/min pump head, quad channel degasser and mixer built-in.

 

HPLC device images: KNAUER Wissenschaftliche Geräte GmbH
Fibre Optic UV Flow Cell
Only the remote fibre optic flow cell is mounted inside the hotcell which frees up valuable space compared to a standard UV detector. HPLC Low Pressure Gradients
Easily perform fully automated quaternary L.P.G. solvent elutions during your radiosynthesis. All parameters are defined in your recipe file. Eliminate Manual Solvent Mixing
Quaternary L.P.G. eliminates the need for manual mixing of your HPLC eluent - It's all done on-line.
Flexible Reactors
Easily swap between the standard 20mL reactor and the small volume 2mL reactor.
Open up new possibilities with the quick change small volume reactors by simplifying the transition to peptide labelling.
LN2 Main Reactor Cooling
Extend the cooling range of both main reactors to -80°C by combining it with our LN2 cooling option. Quad Reactors
Add unparalleled quad reactor capabilities to the FlexLab. The quad reactor option adds heating/cooling, radioactivity monitoring and magnetic stirrer bar mixing to both intermediate vials.
Small volume 2mL reactor Standard 20mL reactor Reactors available in either standard borosilicate glass or high purity glassy carbon. Heating to 220°C & vortex tube compressed air cooling to ≈ 8°C.
Compact Dimensions
Install the FlexLab into virtually any hotcell.
Width 494mm x Height 466mm x Depth 416mm Reduce your labs hotcell costs!
No longer do you need a large and expensive research hotcell to house all the equipment needed for complex multi-step synthesis.
The FlexLab easily fits into compact hotcell's with internal dimensions as small as 72cm x 60cm x 60cm (WxHxD) which can substantially reduce your laboratories costs.
Sensors
Complete & precise monitoring.
Radioactivity Detectors
Monitor every step of the synthesis with 10 collimated radioactivity detectors.
CsI(TI) crystal PIN photodiodes provide a linear response across a large radioactivity range. HPLC Injection Fluid Detectors
Product injection into the HPLC loop's is controlled by two software calibrated optical fluid detectors. They allow on the fly adjustment of the detection threshold so that you never miss your product injection.
x10
Open User Interface System control & visual synthesis recipe development all in one platform.
C-11 Pro2 software interface
The user interface combines both powerful features, yet easy to use tools for both daily operation and synthesis recipe development.
Easy to use open software interface for easy tracer development
Guides you step-by-step during the synthesis
Can be installed on multiple computers for remote synthesis
Recording of all process variables and report generation (21 CFR Part 11 & GMP compliant)
Traditional PC or Touch Screen Tablet Control
Built-in remote diagnostics enabling simplified troubleshooting
Synthesis Reports
Generate and print synthesis reports to satisfy you labs documentation and GMP requirements Real-Time Sensors Trends
All sensor information can be displayed graphically in real-time trends Historical Data Review
Review previous synthesis results as trend graphs with data analysis function,
Graphical Synthesis Recipe Development
Click • Define • Save
SAVE STEP
1. Click Schematic
Click schematic elements such as valves, magnetic stirrers & vacuum pump to turn them on/off. 2. Define parameter
Define parameters such as reactor temperatures, HPLC pump parameters (flow rate & eluent composition) & step parameters (description, time, condition). 3. Save Step
Click the Save Step button and the software will automatically fill-in the Excel recipe step list automatically.
Synthesis recipes are stored as easily editable Excel step list files
Feature Comparison
Lets see how the FlexLab compares to other research synthesizers.
FEATURES
Other F-18 Synthesizers
Dual Reactors Quad Reactors LN2 Reactor Cooling Dual Independent HPLC Purification Quaternary LPG Pump + Degasser Variable Wavelength Fibre
Optic UV/VIS Detector Visual Synthesis Recipe Development Dual SPE HPLC Product Reformulation *
* *
* Optional Feature
Example of Compounds that have been Synthesized on the FlexLab
Radiotracer Imaging Yield @ E.O.S
(not corrected)
18F-FLT Proliferation 10%
18F-FLETT (synthon: 18F-FEA) Proliferation 40%
18F-FMISO Hypoxia 30%
18F-NaphtoQuinone (synthon: 18F-FB) Hypoxia 10%
18F-FES Estrogen 20%
18F-MEL50/54 Melanoma
18F-FDHT Tumor (androgen receptor expression) 20%
18F-FPPRGD2 (synthon: 18F-NFP) Peptide (αv & β3 integrin expression) 10%
18F-GalactoRGD (synthon: 18F-NFP) Peptide (αv & β3 integrin expression) 10%
18F-PBR111 Peripheral Benzodiazepine Receptor 30%
1 1 1 1 1 1 3 3 4 2
Synthon

 

18F-SFB

 

18F-FBEM 25%
Coupling to amine 1 Ackermann, U., Austin Hospital
2 Australian Nuclear Science & Technology Organisation, Lucas Heights
3 Roselt, P., Peter MacCallum Cancer Centre
4 Bourdier, T., Royal Prince Alfred Hospital Radiochemical yield not decay corrected
18F-FEA 18F-FP 18F-NFP 18F-FB 18F-FBA 18F-DBCO Coupling to free amine of single chain antibody Peptide (Cu catalysed click chemistry) Peptide Neovascularisation: coupling to peptide Coupling to hydroxymethyl napthoquinone Coupling to sulfhydryl group of modified single chain antibody Peptide: Cu-free click chemistry Chemistry 25% 90% 20% 20% 35% 40% 10% Yield @ E.O.S
(not corrected) N-Succinimidyl 4-[18F]Fluorobenzoate 2-[18F]Fluoroethylazide 2-[18F]Fluoropropionic acid 4-nitrophenyl 2-[18F]fluoropropionate [18F]Fluorobenzoic acid N-[2-(4[18F]Fluorobenzamido)Ethyl]malemide 4-[18F]Fluorobenzaldehyde [18F]-Dibenzocyclooctyne (free amine on chain)
FlexLab Users
Some of the institutions that are using the FlexLab.
iPHASE Support? Key aspects of our support structure
Spare Parts
Complete stock of spare parts for all synthesizers are available and can be expressed shipped to you to minimise downtime.
Continuing Education
The field of radiochemistry is
ever changing and our education program is there to ensure your team is fully up to date with our latest developments.
Technical Support
You are always a phone call or an email away from an experienced iPHASE engineer or staff member to assist with any queries. Achieving customer satisfaction is our primary objective.
Upgrades
Due to the ever evolving nature of technology, we are continually following the trends and applying the latest technologies to our systems to increase performance, productivity and reliability.
Remote diagnostics
Remote diagnostics are built into every system we make. This enables our experienced engineers to diagnose, test and guide the user to the quickest solution to an issue should it arise.
Hands on Training
Personalized hands on training will ensure your staff will easily learn and master all aspects of our automated technology.
About iPHASE technologies
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iPHASE technologies is a world class designer and manufacturer of automated instrumentation for P.E.T. radiochemistry. By using the latest automation technologies coupled together with intelligent design and class leading software interfaces, our instrumentation is built like no other.
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