C-11 Pro2
Complete C-11 radiotracer production lab
The C-11 Pro2 is our next generation synthesizer designed from years of R&D to simplify the routine production of 11C radiotracers. 11CO2 is trapped at room temp. and rapidly released using a volume optimized molecular sieve column.
Capable of producing either methyl-iodide or methyl-triflate via the "wet" chemistry method, labelling is performed by traditional reaction vial or room temp. loop labelling* and comes with built-in HPLC purification.
The C-11 Pro2 is the complete solution for all your 11C production requirements in the one device.
The C-11 Pro2 has enabled our lab to synthesize an array of more than 10 different 11C compounds, with excellent day-to-day reliability and very good yields and specific activity
Dr. Didier Le Bars
Head of PET Radiochemistry
CERMEP - Imagery Du Vivant, France
DOWNLOAD BROCHURE
Select Your Synthesis Route
The C-11 Pro2 easily allows the selection of the optimal synthesis route.
Step 1:
Concentration of 11CO2 at Room Temperature
Step 2:
Production of Methyl Iodide via Wet Chemistry Method
Step 3A:
Online Conversion of Methyl Iodide into Methyl Triflate
O
O
C
11
O
O
S
O
H
H
H
C
11
C
11
F
F
F
I
H
H
H
C
11
Step 3B:
Reactor Labelling of Precursor with Selected Synthon
Step 3C:
Room Temperature Loop Labelling of Precursor with Selected Synthon
Step 4:
HPLC Purificaiton
Step 5:
SPE Reformulation of HPLC purified product using a disposable kit
Step 6:
Final Injectable Radiotracer
4 Synthesis options
Optimized radiochemistry
I
H
H
H
C
11
O
O
S
O
H
H
H
C
11
C
11
F
F
F
[11C] Methyl-Iodide
[11C]Methyl Iodide is produced in
Reactor 1 via the “wet chemistry”
method and it achieves a > 85%
conversion rate from [11C]carbon
dioxide to [11C]methyl-iodide.
[11C] Methyl-Triflate
The built-in silver triflate column
allows on-line rapid conversion
of [11C]methyl-iodide into [11C]
methyl-triflate.
Loop Labelling
In addition to the traditional reaction vial
labelling method, the C-11 Pro2 allows
labelling via the room temperature loop
labeling method developed by A. Wilson.
Benefits: Generally less by-products are produced as the reaction is done at room temperature resulting in higher labelling yields.
Reactor Labelling:
Reactor 1 is used to generate [11C]methyl-iodide via the "wet chemistry" method.
Reactor 2 is used to preform the traditional labelling reaction method with the desired synthon. HPLC loop is loaded with the reaction mixture using the built-in syringe drive.
Reactor 1
Reactor 2
Two disposable 1.1mL tapered bottom glass reactors allow low volume (as low as 75uL reactions and reduces cross-synthesis contaminants which ensures reproducible results.
High Yield & High Specific Activity
No need to compromise - both can be achieved.
Yield
Specific Activity
Our users have discovered that along with high radiochemical yields, the C-11 Pro2 can achieve high specific activity results as well.
This is due to the C-11 Pro2's design and optimized "wet" chemistry process.
Specific Activity of compound at EOS
3 - 5 Ci / µmol
111 - 185 GBq / µmol
Example of Compounds that have been Synthesized on the C-11 Pro2
10%
Radiotracer
11C-PIB
11C-Choline
11C-PK11195
11C-Methionine
11C-DASB
11C-Flumazenil
11C-PE2I
11C-Acetate
Imaging
Beta-amyloid plaques in neuronal tissue
Prostate cancer
Peripheral benzodiazepine receptor (PBR)
Primary brain tumors
Serotonin transporter
Benzodiazepine receptor antagoinst (GABAA)
Dopamine transporter (DAT)
Early metastatic prostate cancer
Synthesis Time
33 min
20 min
33 min
20 min
33 min
32 min
34 min
16 min
20%
48%
10%
40%
20%
20%
9%
40%
Yield @ E.O.S
(not corrected)
1,4
1
1
2
3
1
3
3
11C-Raclopride
D2 dopamine receptors
34 min
6
11C-Buprenorphine
11C-UCBJ
11C-metoclopramide
Opioid receptors
(binds to SV2A) measure synapse density
P-glycoprotien function at blood brain barrier
35 min
40 min
5%
7%
5%
7%
11C-diprenorphine
Opioid receptors
40 min
40 min
7
7
7
7
Further compounds synthesized by C-11 Pro users
Radiotracer
11C-CUMI
11C-MePPEP
11C-SCH442,416
11C-RO154513
11C-mHED
Imaging
5-HT(1A) agonist
Cannabinoid CB(1) receptor
Adenosine A2a subtype receptor
a5 subtype-GABA-benzodiazepine receptor
Norepinephrine trasporter (NET)
Synthesis Time
≈30 min
≈10-20%
Yield @ E.O.S
(not corrected)
5
1 Austin Hospital, Melbourne Australia
2 Sir Charles Gairdner Hospital, Perth Australia
3 CERMEP - Imagerie Du Vivant, Lyon France
4 Bangkok Hospital Medical Centre, Bangkok Thailand
5 Former Hammersmith Imanet Limited (HIL), London UK
6 Gachon University Hospital, South Korea
7 CEA, France
Radiochemical yield not decay corrected.
Disposable S.P.E. Reformulation Cassette
Simplify GMP requirements
The sterile disposable S.P.E. (solid phase extraction) product reformulation cassette and reagent set help avoid cross-contamination and ensure reproducible results. By using non-proprietary components, the C-11 Pro2 enables users to modify and develop their own cassettes.
Disposable Reactors
Two disposable 1.1mL tapered bottom glass reactors allow low volume (as low as 70uL) reactions and reduce cross-synthesis contaminants which ensures reproducible results.
Fully Automated Wash-Up
Immediately post synthesis, the C-11 Pro2 preforms a fully automated wash-up procedure with 3 different solvents to clean all fixed valves and tubing.
Multi-Synthesis Capability
Preform multiple radiosynthesis in one day thanks to the use of disposable components and fully automated synthesizer wash-up.
Save time and and eliminate the hassle by not needing to perform manual cleaning procedures with the C-11 Pro2.
Compact Dimensions
Install the C-11 Pro2 into virtually any hotcell.
Width 51cm x Height 43.4cm x Depth 34cm
No longer do you need a large and expensive research hotcell to house all the equipment needed for the complete synthesis of C-11 compounds.
The C-11 Pro2 can fit into compact hotcells which reduces your labs hotcell costs.
Compact HPLC System
The C-11 Pro2's compact HPLC contains all the features needed to purify compounds.
HPLC Pump
50mL/min pump head with integrated pressure sensor.
Fibre Optic UV/VIS Detector
Variable wavelength and fibre optic connection to the flow cell.
Only the remote fibre optic flow cell is mounted inside the hotcell which frees up valuable hotcell space compared to traditional UV detectors.
HPLC device images: KNAUER Wissenschaftliche Geräte GmbH
User Interface
System control & synthesis recipe development all in one.
The user interface combines both powerful features, yet easy to use tools for both daily operation and synthesis recipe development.
Easy to use open software interface for easy tracer development
Guides you step-by-step during the synthesis
Can be installed on multiple computers for remote synthesis
Recording of all process variables and report generation (21 CFR Part 11 & GMP compliant)
Traditional PC or Touch Screen Tablet Control
Built-in remote diagnostics enabling simplified troubleshooting
Synthesis Reports
Generate and print synthesis reports to satisfy you labs documentation and GMP requirements
Real-Time Sensors Trends
All sensor information can be displayed graphically in real-time trends
Historical Data Review
Review previous synthesis results as trend graphs with data analysis function
Graphical Synthesis Recipe Development
Click • Define • Save
SAVE STEP
1. Click Schematic
Click schematic elements such as solenoid valves, rotary valves & rotary actuators to turn them on/off or to set positions.
2. Define parameter
Define parameters such as reactor temperatures, MFC flow, syringe / needle positions, HPLC pump parameters & step parameters (description, time, condition).
3. Save Step
Click the Save Step button and the software will automatically fill-in the Excel recipe step list automatically.
Synthesis recipes are stored as easily editable Excel step list files
Feature Comparison
Lets see how the C-11 Pro2 compares to other synthesizers.
Other C-11 Synthesizers
FEATURES
[11C]Methyl Iodide Yield
[11C]Methyl Triflate Conversion
Reactor Labelling
Loop Labelling
Variable Wavelength Fiber
Optic UV/VIS Detector
Visual Synthesis Recipe Development
Disposable SPE Cassette
*
>85%
>50%
* Optional Feature
C-11 Pro Users
Some of the institutions that are using the C-11 Pro.
iPHASE Support
Local Engineers
We have engineers that can perform installations, maintenance, on site repairs & technical support anywhere.
We have engineers located in:
Australia / China
Germany / Poland
UK / Turkey
USA / Canada
Russia / Thailand
Spare parts & stock
We store consumable cassettes, reagents and spare parts in Australia, Germany, USA & Canada to ensure any shipments are delivered in the fastest possible time.
Remote diagnostics
Remote diagnostics are built into every system we make. This enables our experienced engineers to diagnose, test and guide the user to the quickest solution to an issue should it arise.
...............................................................................
