MultiSyn
Compact multi-synthesis radiosynthesizer
The MultiSyn is the most compact, versatile and easy to use disposable cassette radiosynthesizer.
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Multi-Isotope
One synthesizer for all your radiochemistry needs.
Lu
177
Zr
89
Sc
47
F
18
Cu
64
Pb
212
Ga
68
Tb
161
I
124
Ac
225
Standardize and simplify your labs radiochemistry requirements with the one versatile synthesizer. By simply changing the hardware cassette, you can easily switch to another radiosynthesis without any cross-contamination.
Typical Synthesis Route
The MultiSyn can perform the following synthetic steps, or you can setup your own method by simply modifying the hardware cassette and synthesis recipe.
Step 1A:
Elution of the isotope to the MultiSyn
Step 3:
Labelling reaction
Step 4:
S.P.E. purification and reformulation of the labelled product
Step 2:
(Optional)
Pre-purification of the eluted/delivered isotope
Step 5:
Final injectable radiotracer
Cyclotron
F-18
Cu-64
Zr-89
Lu-177
Ac-225
Ga-68
Step 1-B:
Delivery of the isotope to the MultiSyn
Optimized synthesis recipes
Cassettes & Reagents available
Radiotracer recipe files provided free of charge to all users.
Radiotracer
Yield
(not corrected)
Synthesis time
(minutes)
Radiotracer
Synthesis time
(minutes)
Yield
(not corrected)
18F
68Ga
68Ga-PSMA
81%
15
18F-FDG
72%
23
68Ga-DOTATATE
75%
17
18F-NaF
96%
3
68Ga-DOTA-exendin-4
64%
25
18F-PSMA
55%
33
68Ga-FAPI
66%
23
18F-FAPI
25%
35
18F-FCH
coming soon
177Lu
177Lu-PSMA
97%
20
89Zr
177Lu-DOTATATE
>95%
35
89Zr-Durvalumab
75%
30
177Lu-Trastuzumab
88%
65
89Zr-Crefmirlimab Berdoxam
76%
45
225Ac
225Ac-PSMA
>95%
225Ac-DOTATATE
>95%
89Zr-DFOsq-TATE
91%
89Zr-DFOsq-PSMA
90%
26
89Zr-DFOsq-Gmab
93%
161Tb
161Tb-PSMA-I&T
>95%
30
64, 67Cu
64, 67Cu-SARTATE
65%
22 / 42
124I
124I-AT-01
65%
24
Need a compound that is not listed?
Contact our team and we can explore the development of custom cassettes and reagent sets.
Disposable Cassette
The hardware cassettes and reagent sets helps avoid cross-contamination and ensures reproducible results
This enables you to effortlessly meet the most stringent quality control and GMP compliance standards
Hardware cassettes are gamma sterilized and come with Certificate of Conformance.
By using non-proprietary components, the user can modify and develop their own cassettes.
Low metal contaminant materials are used.
Lower your labs consumable costs with low priced cassettes and reagents.
Hardware cassettes are purchased from iPHASE technologies.
Manufactured in Australian GMP clean rooms.
Reagent Set
Reagent sets purchased from iPHASE technologies manufactured by Huyai or ABX.
Each batch of reagents comes with Certificate of Analysis.
Lowest cost consumables in the industry!
Ga-68 Versatility
Compatible with all Ga-68 Generators.
The MultiSyn is compatible with all commercial 68Ga generators.
The MultiSyn has a built-in force limiting syringe drive for generator elution and can perform no pre-purification, as well as cationic or anionic pre-purification of the generators eluate.
HCl
Direct
Saline
SCX
Direct Elution Labelling
The simplest 68Ga synthesis method involves direct labelling of the generators eluate.
This method reduces synthesis time and simplifies system setup.
Generator Pre-purification
Certain reactions require reduction of the acid concentration of the generator eluate and or purification of metal impurities (such as 68Ge) from the eluate to improve reaction conditions.
This is easily accomplished with generator pre-purification and involves trapping the generator eluate onto a purification cartridge and subsequent elution to the reactor with a >99% trap and release efficiency of 68Ga.
Multiple Generator Elution
The MultiSyn can be used to elute multiple generators to increase final radiotracer activity.
The process is automated. No need to rotate any taps manually.
Lutetium-177, Actinium-225, Lead-212 & Terbium-161
Theranostic capabilities
The MultiSyn enables the radiochemist to easily synthesize the following theranostic agents with high isotope recovery.
177Lu-PSMA
177Lu-DOTATATE
161Tb-PSMA-I&T
225Ac-PSMA-IT
225Ac-HA-DOTATATE
177Lu-PSMA / DOTATATE setup
Copper-64 & 67
Novel applications
Easily develop novel methods such as copper radioisotope radiolabelling with the MultiSyn for bot PET imaging and theranostic applications.
"Results show that a consistent, efficient and reliable automated method for the manufacture of 64Cu-SARTATE and 67Cu-SARTATE using the MultiSyn radiosynthesiser has been developed, which results in a high yield of product suitable for use in clinical trials, that can be compliant to GMP requirements" ...... Clarity Pharmaceuticals
Fully automated synthesis of [64&67Cu] SARTATE on the MultiSyn
Flourine-18
Not just for radiometals
In addition to the radiometal radiolabelling capabilities of the MultiSyn, 18F compounds can also be synthesized such as:
18F-FDG
18F-NaF
18F-PSMA
18F-FAPI
Cassette has been tested with up to 480 GBq (13 Ci) of starting 18F for FDG resulting in a 66% uncorrected radiochemical yield.
18F-FDG setup
Zirconium-89
Monoclonal antibody radiolabelling
Fully automate 89Zr monoclonal antibody radiolabelling using the MultiSyn.
Typical fully automated synthesis process involves:
1. Automated cartridge conditioning
2. 89Zr Neutralization
3. Radiolabelling
4. Purification using PD-10 cartridge
89Zr-antibody radiolabelling setup
MultiSyn Solid Target
Dissolution Expansion Module
The MultiSyn solid target dissolution expansion module will enable the MultiSyn to be a complete system for the closed-circuit dissolution of coin based solid targets (64Cu, Zr89 & 68Ga) and purification of the dissolved isotope on the MultiSyn's disposable cassette.
Coin based Solid Target Dissolution & Purification Process:
Target Dissolution:
- MultiSyn pressure tests expansion module's fluidic circuit
- MultiSyn transfers reagents to expansion module
- Drop irradiated target into funnel
- Clamp coin to seal target face
- Peristaltic pump circulates heated acid to dissolve target
Target Purification:
- MultiSyn transfers dissolved target from Expansion Module
- Cartridge purification of dissolved target on MultiSyn's disposable cassette
Cu
Ga
Zr
68
89
64
Dimensions:
21 x 10 x 18cm (HxLxD)
2 Options for location of Expansion Module:
- The expansion module is locate next to the MultiSyn in the same hotcell. This setup requires a transport system for irradiated coin to the hotcell.
or
- The expansion module is located underneath solid target in the cyclotron bunker for direct dropping of coin into expansion module's receiving funnel. This setup does not require a transport system and only one 1/16" tube connection between the MultiSyn and Expansion Module is required.
Targets:
The MultiSyn solid target dissolution module is compatible with the following targets.
24mm diameter circular target.
24mm x 40mm rectangular targets mounted to a backing disk up to 3mm thick.
If you require specific shape target contact us.
Radiation detector monitoring:
1 x Radiation Detector located in the Expansion Module to monitor dissolved solution radioactivity.
3 x Radiation Detectors in the MultiSyn for purification process monitoring.
External Control Electronics
Eliminate radiation damage
The MultiSyn's PLC (programmable logic controller) electronics are housed in an external enclosure located outside of the hotcell.
This eliminates the possibility of damage to the electronic components due to high radiation fields thereby significantly increasing system reliability.
Compact Dimensions
Easily install multiple synthesizers in the one hotcell.
Width 27.5cm x Height 39.7cm x Depth 24cm
Open User Interface
System control & visual synthesis recipe development all in one platform.
Open software provided free of charge to all users.
The user interface combines both powerful features, yet easy to use tools for both daily operation and synthesis recipe development.
- Easy to use open software interface for easy tracer development
- Guides you step-by-step during the synthesis
- Can be installed on multiple computers for remote synthesis
- Recording of all process variables and report generation (21 CFR Part 11 & GMP compliant)
- Traditional PC or Touch Screen Tablet Control
- Built-in remote diagnostics enabling simplified troubleshooting
- Open software system comes standard at no extra cost to the user
Synthesis Reports
Generate and print synthesis reports to satisfy you labs documentation and GMP requirements
Real-Time Sensors Trends
All sensor information can be displayed graphically in real-time trends
Historical Data Review
Review previous synthesis results as trend graphs with data analysis function
Graphical Synthesis Recipe Development
Click • Define • Save
SAVE STEP
1. Click Schematic
Click schematic elements such as solenoid valves and rotary actuators to turn them on/off or to set positions.
2. Define parameter
Define parameters such as reactor temperatures, syringe volumes & step parameters (description, time, condition).
3. Save Step
Click the Save Step button and the software will automatically fill-in the Excel recipe step list automatically.
Synthesis recipes are stored as easily editable Excel step list files
MultiSyn Users
Some of the institutions that are using the MultiSyn.
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